Introduction: Migraine is the second common cause of headache, after the tension headache, that 15 percent of women and 7 percent of men suffering from it. It's connected to some of the main factors such as lifestyle, Nutrition status, and the factors related to stress. The aim of this study is to determination of empowering program effect on the migraine patients.

Method: This randomized clinical trial study, implemented at the Semnan city's headache clinics. 70 patient distributed in two groups, consisting Control and Sample group. Both of the groups filled the "Migraine patient's exclusive quality of life" questionnaire. Control group received the pharmaceutical routine treatment, and Sample group participated in the empowering program. This program includes the holding of two-day workshop and the six-week telephone follow-up.

Results: Results of this study showed that, holding empowering workshop, have significant connection with the "Emotional dimension of quality of life" (P=0.023), "Limiter dimension of quality of life" (P=0.006), "Preventive dimension of quality of life" (P=0.001), and the "General quality of life" (P=0.012).

Conclusion: Empowering workshop had been effective on the improvement of quality of life level, and this simple and inexpensive method could be used as a supplement treatment alongside the pharmaceutical methods.