Introduction: Hypertension is a common disease without symptoms, and if untreated, leads to fatal complications. Using psychological and behavioral therapy for the treatment of patients with hypertension is a low cost strategy. This study aimed to investigate the effect of stress management on anxiety of females with hypertension.

Methods: The research method was quasi-experimental with pre- and post-test and a control group. Forty females with hypertension from patients with hypertension admitted to 22 Bahman Hospital of Masjed-Soleyman were randomly selected, and were divided to two experimental and control groups with 20 subjects. The instrument that assessed anxiety was ANQ. The data obtained in this study was analyzed with univariate analysis. After a one-month follow-up, a test was performed.

Results: There were no statistically significant differences between the experimental and control groups in terms of age, marital status and occupation (P < 0.05). The results showed the effectiveness of group cognitive-behavioral stress management intervention in reducing anxiety (P < 0.0001, F = 17.62).

Conclusions: Stress management training can reduce anxiety levels in females with hypertension and use of this technique as a complementary therapy without complications for patients with hypertension, is recommended.