Introduction: senses of coherence, self-compassion and personal intelligence are the most effective factors on mental health and it can be basic role for the decrease of postpartum depression in women. This research was performed to investigate the relationship between senses of coherence, self compassion and personal intelligence with postpartum depression in women. Method: This research was a descriptive correlation study. Statistical sample of the present study includes 330 women who referred to urmia health centers in 2015. Samples were selected through cluster sampling in several phases. Antonovsky sense of coherence, Neff self-compassion, Mayer’s personal intelligence and Edinburgh postpartum depression questionnaires have been used for data collection. The data was analyzed by Pearson correlation coefficient and multiple regression analysis. P value less than 0.05 was considered significant. Results: Negative correlation was observed between women’ postpartum depression and self-compassion, comprehensibility subscale, meaningfulness subscale, manageability subscale, forming models subscale and guiding choices subscale. The results of multivariate correlation coefficient through Enter showed that the variable of self-compassion and subscales of senses of coherence and personal intelligence may partially (39.6%) explain women’ postpartum depression. Conclusion: According to the negative correlation of postpartum depression with senses of coherence, self-compassion and personal intelligence, it seems that senses of coherence, self-compassion and personal intelligence causes an decrease in women’ postpartum depression.