Introduction: patient’s contextual factors can affect their health information seeking behaviors proper health information seeking behavior can lead to diseases prevention and its improvement. The aim of this study was to examine the effect of contextual factors on the health information seeking behavior of diabetic patients in Isfahan. Method: A survey method was used in this research. The statistical population consisted of 6426 diabetic patients of which 362 patients were selected by a no percentage stratified random sampling. Longo’s information seeking behavior questionnaire was used to collect data and SPSS 20 software were used for analyzing gathered data. Results: Pearson correlation index showed that by controlling age variable there was a direct relation between longevity of diagnosis and some information seeking factors (p< 0.05, r>0). One-way ANOVA test showed that the average score of some factors of diabetic patient’s information-seeking behavior during pregnancy are significantly higher than pre- diabetes and diabetes (p< 0.05). Independent T- test showed that differences between some factors of health information seeking behavior in tow groups of people with a family history of diabetes and people without a family history of diabetes considered statically significant (p< 0.05). Conclusion: Some contextual factors such as longevity of diagnosis, type of the diabetes and family history of diabetes affect on the health information seeking behaviors of diabetic patients. Because of the importance of pre-diabetic patient’s and pregnant diabetic women’s health some arrangements should be set by health authorities in order to better transfer of health information to mentioned diabetic patients. By investigating factors that affect health information seeking behavior of patients with chronic disease their needed information could be transferred to them more effectively and it also can improve patient’s self- care and prevent disease complication.