Introduction: Pressure ulcer is one of the indicators of quality in health care and nursing. Nurses, as one of the key members of the health team, play an important role in the prevention of pressure ulcer in health care centers. Therefore, this study aimed to assess the knowledge, attitude and practice of nurses in the prevention of pressure ulcers.

Methods: This descriptive-correlational study was conducted in 2016. Sampling was performed using the convenience method and consisted Of 382 nurses working in teaching hospitals affiliated to Isfahan University of Medical Sciences. Data collection was performed using a Pieper and self-made three-part questionnaires. The analysis of data was performed by SPSS version 16, using descriptive and analytical statistics. The significance level was considered (as P < 0.05).

Results: In this study, of 427 questionnaires, 382 were completed by the participants (78.3%). The mean scores of knowledge, attitude and practice of nurses in the prevention of pressure ulcers, were respectively 61.1, 63.3 and 62.1, out of 100. The relationships of knowledge, attitude and, practice of nurses, with age, gender, work experience, work place, and courses wound management were not significant (P > 0.05).

Conclusions: Knowledge, attitude and practice of nurses in the prevention of pressure ulcers was were in a relatively favorable levels. Since pressure ulcers is one of the events threatening patient’s safety, managers of health care centers need to plan for empowering of health teams, especially nurses.