Introduction: Considering present inadequacies of educational system in preparing students professionally as well as the medical team’s need for novel and holistic knowledge, the educational methods should be applied which can promote independency, self-directing, reasoning and judgment of the students. The study compared the teacher oriented and learner oriented educational methods.

Methods: A semi-experimental study was conducted to compare the three groups, after and before the intervention. 41 nursing students in their forth semester were recruited in the study. Pre-test and post-test was taken before and after the intervention in all three groups to assess the effects of applied methods on learning.

Results: The results revealed a significant difference in mean scores of post-test among the three groups by means of one-way analysis of variance [f=12.695 ,df (2,38), P<0.001]. All thee methods were effective. Tukey test showed a difference between the self-learning via internet group with the others, but no difference between the other two. The kruskal-wallis test showed a significant difference between students’ level of learning and learning methods (df =2, x²=16.615, P<0.001). C

onclusion: The study showed the effectiveness of all three methods but the effect of self-learning via internet was lower than others. The study recommends future research studies with bigger sample size, also on other course subjects due to its small sample size.