Introduction: Patients with ischemic heart disease always face to risk of another heart attack, so they must endure long term medical treatment. This kind of treatment is possible due to active cooperation of the patients themselve. to play an active role, the patients must be well prepared. The purpose of this research is the study of the effect of instruction and performance of self management program on therapeutic adherence in patient with ischemic heart disease. Method: The study is a randomized controlled trial(RCT) which contains 60 patients who are admitted in Critical Care Unit wards. Who enterd in the study very easily, then divided randomaly into two equal control and experimental groups. All samples were examined with pretest demographic and therapeutic adherence questionnaire at first and then in addition to receive the usual care, the experimental group will participate in the workshop of self management program, during the first week after discharging. Then, it was followed up by phone once a week for 8 weeks. Finally 4 weeks after the last call, the questionnaire of therapeutic adherence were fulfilled again be all samples and it was used statistical test Chi-square test, Fisher exact test, Independent t test and paired t test for analysis. Results: According to findings, there is no meaningful statistical difference due to demographic characteristic and therapeutic adherence between two groups of examination before interference. But after that, based on instructions of self management program, adherence of therapy increased in a meaningful way (p-value<0.001). Conclusion: The result shows that the instruction of self management programs make better adherence of therapy in patients with ischemic heart disease.