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The Relationship between subclinical hypothyroidism with Parathyroid hormone levels and Lipid profiles in patients on dialysis
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Javad Hashemi   , Arash Akaberi , Reza Ghanbari , Ali-Reza Golshan * |
| North Khorasan University of Medical Sciences, Bojnurd, Iran , argolshan@yahoo.com |
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Abstract: (4889 Views) |
Introduction: About 5% to 15% of the general population is affected by subclinical hypothyroidism. This disorder is an important risk factor for cardiovascular disease, which is a major cause of mortality in patients on dialysis. Since the treatment of subclinical hypothyroidism leads to recovery of cardiac muscle plasticity and dyslipidemia, screening is essential.
Methods: The present case-control study was performed during autumn of 2016 at Imam Ali Hospital (Bojnurd, North Khorasan Province, Iran) on patients on dialysis. Overall, 47 patients, including 21 subjects with normal serum TSH and Free T4 as the case group and 26 subjects with normal thyroid hormone as the control group, were selected and their Thyroid Stimulating Hormone (TSH), FT3, FT4, iPTH, triglycerides, cholesterol, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), and calcium were measured. Chi-square test was used to compare the two groups in terms of gender. Independent t-test was used to compare mean age, body mass index, and other factors. Pearson correlation coefficient was used to examine the relationship between variables.
Results: A significant correlation was observed between the mean BMI (22.3 ± 6.8 kg/m2), Triglyceride (TG) (246 ± 126 mg/dl), and Ca (8.5 ± 1.8 mg/dl), and also there were no significant differences in lipid parameters in the case group (P < 0.001). In addition, a significant positive correlation was found between PTH and HDL (P = 0.001) and a negative correlation between PTH and LDL (P = 0.04).
Conclusions: The findings of the current study showed obesity and triglyceridemia in patients with subclinical hypothyroidism deficiency compared to patients without this problem, also it was indicated that PTH has a correlation with dyslipidemia.
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| Keywords: Subclinical hypothyroidism, lipid parameters, PTH |
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Full-Text [PDF 382 kb]
(1364 Downloads)
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Type of Study: Medical |
Subject:
medical
Received: 2016/12/30 | Accepted: 2018/02/10 | Published: 2018/02/10
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| References |
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hashemi J, Akaberi A, Ghanbari R, Golshan A. The Relationship between subclinical hypothyroidism with Parathyroid hormone levels and Lipid profiles in patients on dialysis. IJNR 2018; 12 (6) :45-50 URL: http://ijnr.ir/article-1-1862-en.html
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